Telomerase activity in transthoracic fine needle biopsy aspirates as a marker of peripheral lung cancer

Telomerase activity in transthoracic fine needle biopsy aspirates as a marker of peripheral lung cancer.

BACKGROUND A study was undertaken to evaluate the usefulness of telomerase activity assay in transthoracic fine needle biopsy (TFNB) aspirates collected from peripheral tumours of the lung in predicting the malignant aetiology of lung infiltrations. METHODS 100 patients with a peripheral infiltration of the lung underwent TFNB of the focal lesion. The aspirates were subjected to standard cyto...

Telomerase activity in transthoracic fine-needle biopsy aspirates as a marker of peripheral lung cancer Running title: Telomerase activity in fine-needle biopsy aspirates

Adequacy of core needle biopsy specimens and fine-needle aspirates for molecular testing of lung adenocarcinomas.

OBJECTIVES Molecular testing of lung adenocarcinomas for epidermal growth factor (EGFR) mutations and an anaplastic lymphoma kinase (ALK) translocation is important to guide directed therapy with tyrosine kinase inhibitors. The goal of this study was to determine whether transthoracic computed tomography-guided core needle biopsy (CNB) and fine-needle aspiration (FNA) biopsy specimens were equa...

PERCUTANEOUS TRANSTHORACIC BIOPSY USING TRU-CUT NEEDLE

Biopsies of thoracic lesions guidance. 22 of the 1 12 lesions were mediastinal and 83 were pleuroparenchymal. A large-bore 14-gauge Tru-cut needle was used in all patients. Adequate specimens for histologic examination were obtained in 98%. The overall accuracy was 91 % with 9% false negative and no false positive diagnoses. Despite the large size of the needle, the total number of complic...

Percutaneous transthoracic CT guided biopsies of lung lesions; fine needle aspiration biopsy versus core biopsy

BACKGROUND The purpose of this retrospective study was to compare the results and complication rate in CT guided percutaneous trans-thoracic fine needle aspiration biopsies (FNAB) and core biopsies of lung lesions, and to determine the applicability of these needles. PATIENTS AND METHODS In 242 patients (166 males; 76 females) with mean age of 58.9 years (13-84 years) CT guided biopsies of lu...